Homo sapiens Transcriptome or Gene expression. Homo sapiens

The detection of changes in hematopoiesis after exposure to the plateau environment is more complicated in humans than in experimental animals. In this study, we observed striking differential gene expression pattern related to hematopoiesis after entry to the plateau. The gene expression profile showed some important differences in erythropoiesis-related and immune-related genes, revealing why the majority of people entering the plateau do not have excessive erythrocyte proliferation and are susceptible to infection. The work performed here may provide a typical demonstration of approaches for deciphering the mechanism of high-altitude adaptation in the future.