Crystal Structure of WT HIV-1 Protease (NL4-3) with Inhibitor LR4-45

Crystal Structure of WT HIV-1 Protease (NL4-3) with Inhibitor LR4-45 Descriptor: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-({4-[(1S)-1-hydroxyethyl]benzene-1-sulfonyl}[(2S)-2-methylbutyl]amino)butan-2-yl]carbamate, DIMETHYL SULFOXIDE, Protease Authors: Shaqra, A.M, Kaur, J, Schiffer, C.A. Deposit date: 2025-08-19 Release date: 2025-12-24 Last modified: 2026-01-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Fluorinated HIV-1 protease inhibitors containing chiral hydroxyethylbenzene and indanol as P2' ligands with potent activity against drug-resistant variants. Eur.J.Med.Chem., 304, 2025