RNA-Seq of distal colonic homogenates from intestinal epithelial-specific Sprouty2-deleted mice versus littermate controls
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We asked whether Sprouty2 controls secretory cell differentiation in the distal colon. Loss of Sprouty2 leads to expansion of tuft and goblet cell populations. Sprouty2 loss induced PI3K/Akt signaling, leading to GSK3Ã inhibition and epithelial IL-33 expression Overall design: Comparing the profiles of distal colonic gene expression from VillinCre/Sprouty2-floxxed and littermate Sprouty2-floxxed controls
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2021-02-16
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