CFTR variants in subjects with chronic rhinosinusitis or male infertility (age >30 years).

Top: Chronic rhinosinusitis in NAPS2 controls and cases with 0, 1, or 2 CFTR mutations. Bottom. Self-reported prevalence of male infertility among males over 30 years of age. Odds ratios were calculated comparing CFTR carrier cases in each subcategory against all controls. Because CFTRCF and CFTRBD both affect bicarbonate conductance, we calculated the association and risk associated with the presence of either variant type (shaded).