Gene-sets where there is a nominally significant enrichment of rare variation in the tails of a lipid or lipoprotein measurement (<i>p</i>>0.05) in both WES and WGS.

– Highlighted in bold are gene-sets that are significant after meta-analysis using Stouffer’s method [38] and after adjusting for multiple traits (p< = 0.00037). WES P: permutation p in WES. WGS P: permutation p in WGS. Meta-P: p after meta-analysis using Stouffer’s method. S-VLDL-FC: Free cholesterol in small VLDL. XS-VLDL-C: Cholesterol in very small VLDL. S-VLDL-C: Cholesterol in small VLDL. XS-VLDL-P: Concentration of very small VLDL particles. S-VLDL-CE: Cholesterol esters in small VLDL. S-HDL-P: Concentration of small HDL particles.