Chemical absorption in human skin

Whether from environmental and occupational hazards or from topical
pharmaceuticals, the human skin comes into contact with various chemicals
every day. In vivo experiments not only require large investments of both
time and money, but in vivo experiments can also be unethical due to the
need to intentionally or incidentally expose humans or animals to toxic
chemicals. Comparatively, in vitro experiments offer ethical and financial
advantages when combined with the opportunity to selectively choose
chemicals for experimentation. With in vivo experimentation being so
infeasible, many scientists have chosen to make their in vitro data
available publicly. Using these data, a detailed database containing 73
chemicals was created with a robust set of descriptors to be used in
connection with mathematical modeling to predict diffusion, permeability,
and partition coefficients. This resulting database is tailored to be
easily used in various coding languages.