Crystal structure of human TRF1 TRFH domain in complex with compound 50

Crystal structure of human TRF1 TRFH domain in complex with compound 50 Descriptor: 1,2-ETHANEDIOL, 2-methoxy-~{N}-(2,4,6-trimethylphenyl)ethanamide, CALCIUM ION, ... Authors: Casale, G, Le Bihan, Y.-V, van Montfort, R.L.M, Guettler, S. Deposit date: 2024-11-11 Release date: 2025-11-19 Last modified: 2025-12-03 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Discovery of first-in-class inhibitors of the TRF1:TIN2 protein:protein interaction by fragment screening. Sci Rep, 15, 2025人类端粒重复序列结合因子1（TRF1）的TRFH结构域与化合物50复合物的晶体结构 配体描述：1,2-乙二醇、2-甲氧基-N-(2,4,6-三甲基苯基)乙酰胺、钙离子等 作者：Casale, G、Le Bihan, Y.-V、van Montfort, R.L.M、Guettler, S. 提交日期：2024-11-11 发布日期：2025-11-19 最后更新：2025-12-03 实验方法：X射线衍射（分辨率1.7 Å） 引用文献：通过片段筛选发现首个TRF1:TIN2蛋白质相互作用首创类抑制剂。Sci Rep, 15, 2025