Platelet pathogen reduction technologies alter the microRNA profile of platelet-derived microparticles

The aim of this project was to elucidate the microRNA profile of platelets and of platelet-derived microparticles isolated from clinical platelet concentrates treated or not with pathogen reduction technologies. Overall design: Platelets and platelet-derived microparticles (MPs) were isolated from a pool of clinical platelet concentrates (PCs) prepared in Additive solution or treated (or not) with Mirasol or Intercept.