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CASP4/Caspase-11 expression exacerbates neuroinflammation and amyloid-β deposition during Alzheimer’s disease

NIAID Data Ecosystem2026-05-01 收录

阿尔茨海默病机制

神经炎症与淀粉样蛋白沉积

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE227196 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2024-02-16

蛋白质结构解析

阿尔茨海默病机制

The cryo-EM structure of AV-45 bound type3 amyloid beta 42 fibril. Descriptor: P3(40) Authors: Zhao, Q.Y, Tao, Y.Q, Liu, C, Li, D. Deposit date: 2023-08-15 Release date: 2024-08-21 Last modified: 2025

Protein Data Bank Japan2025-07-02 更新20

AP-2 reduces amyloidogenesis by promoting BACE1 trafficking and degradation in neurons

阿尔茨海默病机制

BACE1转运与降解调控

Cleavage of amyloid precursor protein (APP) by BACE-1 (?-site APP cleaving enzyme-1) is the rate-limiting step in amyloid-? (A?) production and a neuropathological hallmark of Alzheimer's disease (AD)

NIAID Data Ecosystem20

Data Sheet 1_Western diet-induced visceral adipose tissue inflammation promotes Alzheimer’s disease pathology via microglial activation in a mouse model.docx

阿尔茨海默病机制

饮食诱导神经炎症

IntroductionWestern diet (WD)-induced visceral adipose tissue (VAT) inflammation is characterized by adipocyte hypertrophy, hypoxia, and apoptosis. Epididymal white adipose tissue (eWAT), a representa

NIAID Data Ecosystem00

ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism

阿尔茨海默病机制

线粒体代谢

ABCA7 loss-of-function variants are associated with increased risk of Alzheimer's disease (AD). Using ABCA7 knockout human iPSC models generated with CRISPR/Cas9, we investigated the impacts of ABCA7

NIAID Data Ecosystem20

Table_1_Benign Regulation of the Astrocytic Phospholipase A2-Arachidonic Acid Pathway: The Underlying Mechanism of the Beneficial Effects of Manual Acupuncture on CBF.DOC

阿尔茨海默病机制

针刺调控脑血流

BackgroundThe astrocytic phospholipase A2 (PLA2)-arachidonic acid (AA) pathway is crucial in understanding the reduction of cerebral blood flow (CBF) prior to cognitive deterioration. In complementary

NIAID Data Ecosystem10

CASP4/Caspase-11 expression exacerbates neuroinflammation and amyloid-β deposition during Alzheimer’s disease

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