Triclabendazole Resistant Fascioliasis

Fascioliasis, an important but neglected human fluke infection, is becoming resistant to triclabendazole, the only highly active medication available to treat humans. The mechanism of resistance is unknown and there are no genetic markers to detect it. This project aims to evaluate the whole Fasciola genome and transcriptome of susceptible and resistant parasites to identify genetic markers and resolve the mechanisms of triclabendazole resistance, which will facilitate the production of tools to tackle its emergence and spread.