LpxC from A.Aaeolicus in complex with the MMP inhibitor 4-[[4-(4-chlorophenoxy)phenyl]sulfanylmethyl]tetrahydropyran-4-carbohydroxamic acid - compound 2

LpxC from A.Aaeolicus in complex with the MMP inhibitor 4-[[4-(4-chlorophenoxy)phenyl]sulfanylmethyl]tetrahydropyran-4-carbohydroxamic acid - compound 2 Descriptor: 4-({[4-(4-chlorophenoxy)phenyl]sulfanyl}methyl)-N-hydroxytetrahydro-2H-pyran-4-carboxamide, CHLORIDE ION, IMIDAZOLE, ... Authors: Olivier, N.B. Deposit date: 2014-07-19 Release date: 2014-10-01 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.34 Å) Cite: Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors. Acs Med.Chem.Lett., 5, 2014

与基质金属蛋白酶（MMP）抑制剂4-[[4-(4-氯苯氧基)苯基]硫甲基]四氢吡喃-4-碳羟肟酸（化合物2）结合的A. aeolicus来源的LpxC。配体描述：4-({[4-(4-氯苯氧基)苯基]硫基}甲基)-N-羟基四氢-2H-吡喃-4-甲酰胺、氯离子、咪唑等。作者：Olivier, N.B. 保藏日期：2014-07-19，发布日期：2014-10-01，最后修改日期：2024-05-08。实验方法：X射线衍射（分辨率1.34 Å）。引用文献：《基于四氢吡喃的LpxC抑制剂的合成、结构与构效关系》，发表于《ACS药物化学通讯》（Acs Med.Chem.Lett.），第5卷，2014年。