Main features of the tools used in this study to analyse NRPS.

*All types of domains means that the tool outputs all the known domains for the enzymes they cover. “A domains” is for adenylation domains; “KS” for ketosynthase and “C” for condensation domains.**SMILES (simplified molecular-input line-entry system) format is a string representation of chemical structures.***NaPDoS works better with one domain at a time.