SRSF1 knockdown alleviates the ribosomal stress-induced inhibition of cell proliferation through the MAPK signaling pathway

To investigate the regulatory function of the RNA-binding protein SRSF1 in short-term starvation-induced ribosomal stress (RS), we established the 293T starvation model and the SRSF1 knockdown model. We then performed gene expression profiling using the data obtained from RNA-seq of 293T cells from 3 different treatments. Overall design: Comparative gene expression profiling of RNA-seq data of 293T cells and their KD derivatives (shSRSF1, shSRPK1, and shUPF1).