Autoimmune uveitis in Behçet's disease and Vogt-Koyanagi-Harada disease differ in tissue immune infiltration and T cell clonality
收藏科学数据银行2023-07-11 更新2026-04-23 收录
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资源简介：
Non-infectious uveitis is often secondary to systemic autoimmune diseases, with Behçet's disease (BD) and Vogt-Koyanagi-Harada disease (VKHD) as the two most common causes. Uveitis in BD and VKHD can show similar clinical manifestations, but the underlying immunopathogenesis remains unclear. To understand immune landscapes in inflammatory eye tissues, we performed single-cell RNA paired with T cell receptor (TCR) sequencing of immune cell infiltrates in aqueous humour from six patients with BD (N = 3) and VKHD (N = 3) uveitis patients. Single-cell analyses of ocular tissues reveal distinct landscapes of immune cell infiltration and T cell clonal expansions between VKHD and BD uveitis. Preferential involvements of pro-inflammatory CD4+ Th1 cells in VKHD and cytotoxic CD8+ T cells in BD suggest a difference in disease immunopathogenesis and can guide precision disease management.
提供机构：
Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia; Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University; Ian Frazer Centre for Children’s Immunotherapy Research, Children’s Health Research Centre, Faculty of Medicine, The University of Queensland, Brisbane QLD, Australia; Hongjian Sun
创建时间：
2022-08-22
