Crystal Structure of the bromodomain of human BAZ2B in complex with 1-{1-[2-(hydroxymethyl)phenyl]-7-phenoxyindolizin-3-yl}ethanone (GSK2847449A)

Crystal Structure of the bromodomain of human BAZ2B in complex with 1-{1-[2-(hydroxymethyl)phenyl]-7-phenoxyindolizin-3-yl}ethanone (GSK2847449A) Descriptor: 1,2-ETHANEDIOL, 1-{1-[2-(hydroxymethyl)phenyl]-7-phenoxyindolizin-3-yl}ethanone, Bromodomain adjacent to zinc finger domain protein 2B Authors: Chaikuad, A, Felletar, I, Chung, C.W, Drewry, D, Chen, P, Filippakopoulos, P, Fedorov, O, Krojer, T, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2013-01-14 Release date: 2013-01-23 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B. J.Med.Chem., 59, 2016

人源BAZ2B溴结构域（bromodomain）与1-{1-[2-(羟甲基)苯基]-7-苯氧基吲哚嗪-3-基}乙酮（GSK2847449A）的复合物晶体结构
描述项：1,2-乙二醇，1-{1-[2-(羟甲基)苯基]-7-苯氧基吲哚嗪-3-基}乙酮，锌指结构域相邻溴结构域蛋白2B
作者：Chaikuad, A、Felletar, I、Chung, C.W、Drewry, D、Chen, P、Filippakopoulos, P、Fedorov, O、Krojer, T、von Delft, F、Arrowsmith, C.H、Edwards, A.M、Bountra, C、Knapp, S、结构基因组学联盟（Structural Genomics Consortium, SGC）
提交日期：2013-01-14
发布日期：2013-01-23
最后修改日期：2023-09-20
检测方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.7埃
引用：《GSK2801的发现与表征：一种针对BAZ2A与BAZ2B溴结构域的选择性化学探针》，《药物化学杂志》（J. Med. Chem.），59卷，2016年