CATHeterization GENetics (CATHGEN)

The CATHGEN biorepository consists of biological samples collected on 9334 sequential consenting individuals undergoing cardiac catheterization at Duke University Medical Center between 2001 and 2010 inclusive. The Institutional Review Board informed consent allowed for 50 mL of blood to be collected from fasting patients through the femoral arterial sheath during the catheterization procedure. Three 7.5 mL EDTA tubes for DNA extraction are stored at -80°C. The Duke Database for Cardiovascular Disease (DDCD) provides the bulk of the clinical data used for analysis. Follow-up includes mortality information gleaned from the National Death Index and Social Security Death Index plus follow-up phone calls and written questionnaires regarding MI, stroke, re-hospitalization, coronary re-vascularization procedures, smoking, exercise, and medication use.

CATHGEN生物样本库收录了2001年至2010年（含首尾年份）期间，在杜克大学医学中心接受心脏导管介入术的9334名连续入组且签署知情同意书的患者的生物样本。本研究的伦理审查委员会（Institutional Review Board）批准可在导管介入手术过程中，通过股动脉鞘管从空腹患者体内采集50mL血液。用于DNA提取的3支7.5mL乙二胺四乙酸（EDTA）抗凝管，均储存于-80℃低温环境中。杜克心血管疾病数据库（Duke Database for Cardiovascular Disease，DDCD）提供了本分析所用的绝大部分临床数据。随访数据涵盖从国家死亡索引（National Death Index）与社会安全死亡索引获取的死亡信息，辅以随访电话调研以及针对心肌梗死（Myocardial Infarction，MI）、脑卒中、再住院、冠状动脉血运重建术、吸烟状况、运动习惯与用药情况的书面调查问卷。