Crystal structure of Torpedo Californica acetylcholinesterase in complex with 8-[(3-Chloro-6,7,10,11-tetrahydro-9-methyl-7,11-methanocycloocta[b]quinolin-12-yl)amino]-N-(4-hydroxy-3-methoxybenzyl)octanamide

Crystal structure of Torpedo Californica acetylcholinesterase in complex with 8-[(3-Chloro-6,7,10,11-tetrahydro-9-methyl-7,11-methanocycloocta[b]quinolin-12-yl)amino]-N-(4-hydroxy-3-methoxybenzyl)octanamide Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 8-[(3-Chloro-6,7,10,11-tetrahydro-9-methyl-7,11-methanocycloocta[b]quinolin-12-yl)amino]-N-(4-hydroxy-3-methoxybenzyl)octanamide, Acetylcholinesterase, ... Authors: Coquelle, N, Colletier, J.P. Deposit date: 2020-09-28 Release date: 2021-10-06 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.996 Å) Cite: Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice. J.Med.Chem., 64, 2021

加州电鳐（Torpedo Californica）乙酰胆碱酯酶（Acetylcholinesterase）与8-[(3-氯-6,7,10,11-四氢-9-甲基-7,11-亚甲基环辛并[b]喹啉-12-基)氨基]-N-(4-羟基-3-甲氧基苄基)辛酰胺的复合物晶体结构
描述项：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、8-[(3-氯-6,7,10,11-四氢-9-甲基-7,11-亚甲基环辛并[b]喹啉-12-基)氨基]-N-(4-羟基-3-甲氧基苄基)辛酰胺、乙酰胆碱酯酶等
作者：Coquelle, N.、Colletier, J.P.
提交日期：2020-09-28
发布日期：2021-10-06
最后修改日期：2024-11-20
实验方法：X射线衍射（分辨率1.996 Å）
引用文献：《发现一种兼具抗氧化活性的乙酰胆碱酯酶与丁酰胆碱酯酶（Butyrylcholinesterase）强效双重抑制剂，可缓解老年APP/PS1小鼠的阿尔茨海默样病理》，刊载于《药物化学杂志》（J. Med. Chem.），2021年，第64卷