Dataset from Feasibility, Safety, Tolerance and Assessment of LACTIN-V Use in a Cohort of Pregnant Women at Risk of Preterm Birth

Preterm birth (PTB) is the primary cause of infant death worldwide. It has been shown that a
vaginal microbiota deplete in Lactobacillus species is a risk factor for preterm labour.
Conversely a vaginal microbiota dominated by Lactobacillus crispatus appears to be protective
for these adverse outcomes. A wide range of 'over the counter' Lactobacillus spp. containing
products targeted at 'vaginal health' and formulated for vaginal administration are
available, but most of them do not contain vaginal species of Lactobacillus. The primary aim
of this study is to determine whether vaginal supplementation with L. crispatus CTV-05 is
associated with colonisation.