Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z3765495818 (A71EV2A-x0202)

Protein Data Bank Japan2024-10-16 更新2026-04-19 收录

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Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z3765495818 (A71EV2A-x0202) Descriptor: (4R)-imidazo[1,2-b]pyridazine-3-sulfonamide, DIMETHYL SULFOXIDE, Protease 2A, ... Authors: Lithgo, R.M, Fairhead, M, Koekemoer, L, Balcomb, B.H, Capkin, E, Chandran, A.V, Golding, M, Godoy, A.S, Aschenbrenner, J.C, Marples, P.G, Ni, X, Thompson, W, Tomlinson, C.W.E, Wild, C, Winokan, M, Xavier, M.-A.E, Fearon, D, von Delft, F. Deposit date: 2024-04-04 Release date: 2024-04-24 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals. Biorxiv, 2024

柯萨奇病毒A16型（Coxsackievirus A16）(G-10株)2A蛋白酶晶体学片段筛选联合沉积——柯萨奇病毒A16型（Coxsackievirus A16）(G-10株)2A蛋白酶与Z3765495818（A71EV2A-x0202）复合物的晶体结构描述项：(4R)-咪唑并[1,2-b]哒嗪-3-磺酰胺、二甲基亚砜、2A蛋白酶…… 作者：Lithgo, R.M、Fairhead, M、Koekemoer, L、Balcomb, B.H、Capkin, E、Chandran, A.V、Golding, M、Godoy, A.S、Aschenbrenner, J.C、Marples, P.G、Ni, X、Thompson, W、Tomlinson, C.W.E、Wild, C、Winokan, M、Xavier, M.-A.E、Fearon, D、von Delft, F 沉积日期：2024-04-04 发布日期：2024-04-24 最后修改日期：2024-10-16 实验方法：X射线衍射（分辨率1.47埃）引用文献：《柯萨奇病毒A16型2A蛋白酶的晶体学片段筛选发现广谱抗肠病毒药物开发新机遇》，BioRxiv，2024

创建时间：

2024-04-04