Additional file 5 of Reconstructed colorectal cancer model to dissect the anti-tumor effect of mesenchymal stromal cells derived extracellular vesicles
Mouse models have been developed to investigate colorectal cancer etiology and evaluate new anti-cancer therapies. While genetically engineered and carcinogen-induced mouse models have provided impor
Here, we used single-cell RNA sequencing (scRNA-seq) technology which can provide unbiased cell types and cell-specific gene expression, to deeply sequenced a tumor tissue of a spontaneous CRC mouse.
Colorectal cancer (CRC) remains the third most common cancer in the US, with 15% of cases displaying Microsatellite Instability (MSI) secondary to Lynch Syndrome (LS) or somatic hypermethylation of th