Insulin receptor signalling cascade

Autophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the autophosphorylation of the insulin receptor is its internalisation into an endosome, which downregulates its signalling activity.

胰岛素受体的自磷酸化引发一系列由SHC或IRS介导的信号传导事件，进而激活Ras/RAF和MAP激酶级联反应。胰岛素受体自磷酸化的第二个效应是其被内化至内体中，从而下调其信号传导活性。