Beyond pregnancy: long-term maternal and offspring health implications of pregnancy disorders

Supplementary Figures & Tables for the thesis "Beyond pregnancy: long-term maternal and offspring health implications of pregnancy disorders" by Renée J. Burger. (2024-06-12). This thesis investigates long-term health implications of pregnancy disorders for the mother and the child. Part I focusses on the link between pregnancy and maternal cardiovascular health. Burger and colleagues show in this thesis that women, irrespective of ethnicity, are at increased risk of CVD after a complicated pregnancy. They find that, despite pregnancy complications being a clear risk factor for CVD, adding it as criterium for formal CVD risk screening does not aid in the identification of those at risk. Nevertheless, they argue that pregnancy disorders offer a window of opportunity to identify this increased risk early in life and to modify it in order to reduce the burden of CVD later in life. To do so, better tools to predict both pregnancy disorders and CVD after pregnancy, and better screening and intervention strategies aimed at risk reduction are needed. Part II of the thesis studies cognitive development of children in relation to pregnancy complications, interventions around birth and sociodemographic characteristics during pregnancy. They find that being born prematurely, having low birthweight for gestational age, low socio-economic status or being born after labour induction is associated with slightly reduced average school performance at age 12. They emphasize the need to incorporate long-term outcomes in future research, and to appropriately weigh short- and long-term risks in decisions around timing of labour and other interventions.

论文《超越妊娠：妊娠并发症对母亲与子代的长期健康影响》（作者Renée J. Burger，发布于2024年6月12日）的补充图表集。本论文探究了妊娠并发症对母亲及子代的长期健康影响。第一部分聚焦于妊娠与母亲心血管健康之间的关联。Burger及其团队在本研究中证实，无论种族背景如何，经历过复杂妊娠的女性罹患心血管疾病（Cardiovascular Disease, CVD）的风险均会升高。研究团队发现，尽管妊娠并发症是心血管疾病明确的危险因素，但将其纳入正式的心血管疾病风险筛查标准，并不能有效识别高危人群。尽管如此，研究团队仍指出，妊娠并发症为我们提供了一个窗口期，可在生命早期识别这类升高的疾病风险并加以干预，从而降低晚年罹患心血管疾病的疾病负担。为此，亟需开发能够同时预测妊娠并发症与产后心血管疾病的工具，并优化旨在降低风险的筛查与干预策略。论文第二部分则围绕妊娠并发症、分娩相关干预措施以及妊娠期间的社会人口学特征，探究儿童的认知发育情况。研究团队发现：早产、胎龄别低出生体重、社会经济地位低下，以及引产分娩的儿童，在12岁时的平均学业表现均略有下降。研究团队强调，未来的研究应纳入长期结局指标，并在分娩时机选择与其他干预措施的决策中，合理权衡短期与长期风险。