Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(6-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine

Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(6-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine Descriptor: COBALT (II) ION, GLYCEROL, Methionine aminopeptidase 1, ... Authors: Addlagatta, A, Kishor, C, Arya, T. Deposit date: 2012-12-28 Release date: 2013-12-11 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases J.Med.Chem., 56, 2013

截短（缺失1-89位氨基酸序列）的人类1型甲硫氨酸氨肽酶（methionine aminopeptidase Type 1）与N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(6-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine结合形成复合物的晶体结构。
描述项：钴(II)离子、甘油、1型甲硫氨酸氨肽酶等。
作者：Addlagatta, A、Kishor, C、Arya, T
提交日期：2012-12-28
发布日期：2013-12-11
最后修改日期：2024-03-20
实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.7埃（Å））
引用文献：《针对I型甲硫氨酸氨肽酶的物种特异性抑制剂的鉴定、生化及结构评估》，发表于《J.Med.Chem.》（《Journal of Medicinal Chemistry》），2013年，第56卷。