Homo sapiens Transcriptome or Gene expression

In the current study we sought to investigate systemic effects of aneurysmal subarachnoid hemorrhage (SAH) through analysis of gene expression profiles in peripheral blood cells by means of deep transcriptome sequencing. We included 19 patients in the acute phase of IA rupture (RAA, first 72 hours), 20 patients in the chronic phase (RAC, 3-15 months), and 20 controls. We performed a global analysis of protein coding and non-coding gene variants regulated by SAH. We investigated expression of specific gene variants that may lead to production of functionally distinct protein isoforms and influence systemic response to IA rupture.