Structure of the catalytic domain of the Bacillus circulans alpha-1,6 Mannanase in complex with an alpha-1,6- alpha-manno-cyclophellitol carbasugar-stabilised trisaccharide inhibitor

Structure of the catalytic domain of the Bacillus circulans alpha-1,6 Mannanase in complex with an alpha-1,6- alpha-manno-cyclophellitol carbasugar-stabilised trisaccharide inhibitor Descriptor: (1~{S},2~{R},3~{S},4~{R},5~{R})-5-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol, (1~{S},4~{S},5~{R})-6-(hydroxymethyl)cyclohexane-1,2,3,4,5-pentol, 1,2-ETHANEDIOL, ... Authors: Schroeder, S, Offen, W.A, Jin, Y, De Boer, C, Enoterpi, J, Marino, L, van der Marel, G.A, Codee, J.D.C, Overkleeft, H.S, Davies, G.J. Deposit date: 2020-06-09 Release date: 2021-04-28 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Development of Non-Hydrolysable Oligosaccharide Activity-Based Inactivators for Endoglycanases: A Case Study on alpha-1,6 Mannanases. Chemistry, 27, 2021

环状芽孢杆菌（Bacillus circulans）α-1,6-甘露聚糖酶催化结构域与α-1,6-α-甘露糖基环斐糖醇（cyclophellitol）碳环糖稳定化三糖抑制剂的复合物结构。配体描述：(1S,2R,3S,4R,5R)-5-(羟甲基)环己烷-1,2,3,4-四醇、(1S,4S,5R)-6-(羟甲基)环己烷-1,2,3,4,5-五醇、1,2-乙二醇（1,2-ETHANEDIOL）等。作者：Schroeder, S、Offen, W.A、Jin, Y、De Boer, C、Enoterpi, J、Marino, L、van der Marel, G.A、Codee, J.D.C、Overkleeft, H.S、Davies, G.J。存档日期：2020年6月9日；发布日期：2021年4月28日；最后修改日期：2024年10月9日。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.35埃）。引用文献：《内切聚糖酶不可水解寡糖活性导向灭活剂的开发：以α-1,6-甘露聚糖酶为例》，《Chemistry》，27卷，2021年。