Number of potential bioactive peptides (per protein molecule) predicted to be released and AD1 value after small intestinal digestion for gut endogenous proteins secreted in the small intestine based on an in silico digestion model.

1AD value is the frequency of occurrence of bioactive peptides after digestion of the protein, calculated as where, aD is the number of identified bioactive peptides present after the simulated (in silico) digestion and N is the total number of amino acid residues within the protein.22 ACE-inhibitor, 5 regulating (ion flow-, stomach mucosal membrane activity-, phosphoinositol mechanism peptide-), 6 antioxidative, 8 inhibitor (dipeptidyl peptidase IV inhibitor-, dipeptidyl-aminopeptidase IV inhibitor-, dipeptidyl carboxypeptidase-, CaMPDE-, neuropeptide-), 9 hypotensive.3The total number of peptides released is a summation of all the bioactive peptides predicted to be released after digestion of the intact proteins.4Some of the predicted bioactive peptides have more than one activity. Hence the total number of bioactive peptides released may be less than the summation of the number of bioactive peptides from the individual activity categories.5Pancreatic triacylglycerol is predicted to release 1 immunostimulating peptide. Peptide not shown in the table, but is reflected in the corresponding total number of predicted bioactive peptides released.