Study of risk factors for melanoma

Since 1988, individuals affected by melanoma in Southern Sweden has been interviewed and the cohort now consists of 3000 cases. For each case, two controls are randomly selected from the Skåne population registry and matched for sex, age and place of residence. The same questions have been sent also to the controls. These questions concern, among others, past illnesses, medication, exposure to UV light, alcohol, smoking, use of oral contraceptivesion and education. All patients with familial melanoma have been analyzed for a CDKN2A mutation. During 1995-96 blood was collected from all patients, but beyond that they have only blood collected from cases with familiar melanoma, cases aged under 40 and cases with multiple melanoma. The study is still ongoing. Purpose: The aim of the study is to create a cohort of patients with melanoma and controls to study risk factors for the disease.自1988年起，研究人员对瑞典南部罹患黑色素瘤（melanoma）的患者开展访谈随访，目前该队列（cohort）已纳入3000例病例。针对每一例病例，研究人员从斯科讷（Skåne）人口登记库中随机选取2名对照个体，并按性别、年龄及居住地进行匹配。研究人员亦向对照个体发放了相同的调查问卷，问卷内容涵盖既往病史、用药史、紫外线暴露情况、饮酒习惯、吸烟史、口服避孕药使用情况及受教育程度等。所有家族性黑色素瘤（familial melanoma）患者均接受了CDKN2A基因突变检测。1995年至1996年间，研究人员采集了所有病例的血液样本；除此之外，仅针对家族性黑色素瘤病例、40岁以下病例及多发性黑色素瘤病例采集了血液样本。本研究目前仍在进行中。 研究目的： 本研究旨在构建黑色素瘤患者与对照个体组成的队列，以探究该疾病的危险因素。