To help elucidate mechanistic differences between lengthening and shortening muscle contractions we compared changes in gene expression within 24 h of an acute bout of each type of contraction in the
The cardiac thin filament regulates actomyosin interactions through calcium-dependent alterations in the dynamics of cardiac troponin and tropomyosin. Over the past several decades, many details of th
In biomolecular systems, the mechanical transfer of free energy occurs with both high efficiency and high speed. It is shown here that such a transfer can be achieved only if the participating free-en
Structure of cardiac native thin filament at pCa=5.8 having upper and lower troponins in Ca2+ bound state Descriptor: Actin, alpha skeletal muscle, Tropomyosin alpha-1 chain, ... Authors: Galkin, V.E,