Characteristics* associated with efficacy of initial antiretroviral therapy: all groups.

*Study phase, genotype/CD4 eligibility restrictions, pills and doses per day were significant on univariable analysis but not multivariable. Co-infection with hepatitis B or C were excluded from the multivariable analysis because >20% of groups were missing data.†Study sponsorship, placebo use, country/region of recruitment, haemoglobin/viral load/liver function eligibility restrictions, race, risk factors for HIV infection, sex, previous AIDS events, pre-treatment viral load/CD4 count, dosing relative to food, serious adverse events, and clinical/laboratory adverse events of at least moderate severity were variables not significant on univariable analysis.‡Coefficient represents the adjusted percentage difference in outcomes relative to a unit increase in any variable (or relative to the reference variable within a category).SD, standard deviation; CI, confidence interval; ITT, intention-to-treat; M = F, missing equals failure; NC = F, non-completer equals failure; TLOVR, time to loss of virological response; TDF, tenofovir; FTC, emtricitabine; AZT, zidovudine; 3TC, lamivudine; d4T, stavudine; ddI, didanosine; ABC, abacavir; ELV, elvucitabine; NRTI, nucleoside reverse transcriptase inhibitor; NNRTI, non-nucleoside reverse transcriptase inhibitor; PI, protease inhibitor; INSTI, integrase strand transfer inhibitor; CCR5, chemokine receptor 5 inhibitor.