Facile 5-Endo Amidyl Radical Cyclization Promoted by Vinylic Iodine Substitution
收藏NIAID Data Ecosystem2026-03-06 收录
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BF3·OEt2-catalyzed atom-transfer radical addition of iodoacetamides to alkynes yielded the corresponding vinyl iodides, which upon treatment with tBuOCl and I2 afforded γ-lactam derivatives in moderate to good yield. The mechanism was proposed to be 5-endo amidyl radical cyclization, and vinylic iodine substitution provided the driving force for the cyclization.
创建时间：
2016-05-12
