Assessment of predicted helical packing arrangements for the 17 sequences where all interactions were successfully predicted.

Arrangements were compared to a two-dimensional slice taken from the respective crystal structures and assessed based on the alignment between the helices in the predicted arrangement and in the slice; in 9 cases there was overlap for all helices (2F95:A, 1E12:A, 1XIO:A, 2D57:A, 1FFT:C, 1JB0:L, 1C17:A, 1R3J:C, 2AHY:A). In 3 cases, there were no observed helix-helix interactions therefore no arrangement could be predicted (1VCR:A, 1YQ3:D, 1ZOY:C). In 3 cases, the arrangement predicted a circular configuration whereas the correct arrangement was approximately linear (1DXR:M, 2AXT:D, 2AXT:A).