Plasmodium parasite proteomics of iron deficiency

Iron deficiency anaemia and Plasmodium infection represent significant global health challenges with overlapping geographical distributions, particularly affecting pregnant women in Africa. Previous evidence suggests complex interactions between iron status and malaria susceptibility. However, the precise mechanisms and clinical implications of this relationship remain poorly understood. Here,we explored direct effects of iron chelation on cultured P. falciparum parasites through proteomic analyses, which was found to primarily affect processes involved in host cell invasion, protein export, and nutrient acquisition