Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with 3-(2-(4-(3-ethyl-3-phenylpyrrolidin-1-yl)-6-methyl-2-oxopyridin-1(2H)-yl)ethyl)-8-(imidazo[1,5-a]pyrazin-8-yl)-1,3,8-triazaspiro[4.5]decan-2-one

Structure of full-length amyloidogenic immunoglobulin light chain H9 in complex with 3-(2-(4-(3-ethyl-3-phenylpyrrolidin-1-yl)-6-methyl-2-oxopyridin-1(2H)-yl)ethyl)-8-(imidazo[1,5-a]pyrazin-8-yl)-1,3,8-triazaspiro[4.5]decan-2-one Descriptor: 3-(2-{4-[(3R)-3-ethyl-3-phenylpyrrolidin-1-yl]-6-methyl-2-oxopyridin-1(2H)-yl}ethyl)-8-[(4R)-imidazo[1,5-a]pyrazin-8-yl]-1,3,8-triazaspiro[4.5]decan-2-one, H9 Immunoglobulin Light Chain, PHOSPHATE ION Authors: Lederberg, O.L, Kelly, J.W, Yan, N.L, Wilson, I.A, Stanfield, R.L. Deposit date: 2024-03-05 Release date: 2024-12-18 Last modified: 2024-12-25 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Discovery of Potent and Selective Pyridone-Based Small Molecule Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains. J.Med.Chem., 67, 2024

全长淀粉样生成性免疫球蛋白轻链（immunoglobulin light chain）H9与3-(2-(4-(3-乙基-3-苯基吡咯烷-1-基)-6-甲基-2-氧代吡啶-1(2H)-基)乙基)-8-(咪唑并[1,5-a]吡嗪-8-基)-1,3,8-三氮杂螺[4.5]癸烷-2-酮形成的复合物结构
描述项：3-(2-{4-[(3R)-3-乙基-3-苯基吡咯烷-1-基]-6-甲基-2-氧代吡啶-1(2H)-基}乙基)-8-[(4R)-咪唑并[1,5-a]吡嗪-8-基]-1,3,8-三氮杂螺[4.5]癸烷-2-酮、H9免疫球蛋白轻链、磷酸根离子（PHOSPHATE ION）
作者：Lederberg, O.L、Kelly, J.W、Yan, N.L、Wilson, I.A、Stanfield, R.L
存储日期：2024-03-05
发布日期：2024-12-18
最后修改日期：2024-12-25
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.7 Å
引用：《淀粉样生成性免疫球蛋白轻链的强效选择性吡啶酮类小分子动力学稳定剂的发现》，《药物化学杂志》（J.Med.Chem.），第67卷，2024年