Dissecting_the_genetic_basis_of_melioidosis_infection_II

Burkholderia pseudomallei (Bp) is an environmental bacterium and a causative agent for melioidosis, an infection that can be rapidly fatal. Humans can acquire Bp through direct contact with contaminated soil or water, yet not all exposure results in disease. We hypothesise that genetic variations in both bacteria and host may contribute to whether individuals would develop the disease and how severe the disease is. Moreover, people with diabetes are more susceptible to developing melioidosis. For each genetic variant, we will investigate how patient diabetic status would modulate disease severity.