Amino acid changes observed in integrase sequences from raltegravir-treated HIV-2 patients.

aPatients that did not receive raltegravir-containing treatment are not included in this table.bGenotypic analyses were performed on consensus (bulk) sequences unless otherwise indicated.cThese changes appeared in cloned PCR products amplified from a single patient.dThis combination of replacements was observed in two study subjects.eReplacements listed for Charpentier et al. are the changes observed at time of virologic failure. Upon further raltegravir treatment, the predominant genotypes in the two patients harboring Q148K/R changed to G140S+Q148R, and the consensus sequence of the patient with E92E/Q+Y143H/R+N155H changed to E92E/A/P/Q+N155H.fN155H variants emerged in two study subjects. The exact combinations of changes were not specified.