LncRNA LUCAT1 and exosomal MIF induced by Helicobacter pylori promotes M2 macrophage polarization in gastric cancer

H. pylori infection induces upregulation of the long non-coding RNA LUCAT1 in gastric cancer cells, which facilitates the exosomal transfer of MIF (macrophage migration inhibitory factor) to the tumor microenvironment. This process shifts macrophages from the M0 to M2 phenotype, contributing to an aggressive gastric cancer progression by enhancing cell proliferation, migration, and invasion. The research suggests potential preventive and therapeutic strategies for gastric cancer by targeting LUCAT1 and MIF, highlighting the critical role of lncRNA-mediated mechanisms in H. pylori driven-cancer development. RNA sequencing was performed on GC and normal cells exposed to H. pylori. LncRNA expression changes were analyzed, and key candidates were validated through functional assays. *************************************************************** Submitter states that missing raw files are due to file loss. ***************************************************************