CYP3A4 bound to an inhibitor

CYP3A4 bound to an inhibitor Descriptor: (2R)-3-phenyl-2-({(2S)-3-phenyl-2-[2-(pyridin-3-yl)acetamido]propyl}sulfanyl)-N-[(pyridin-3-yl)methyl]propanamide, Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE Authors: Sevrioukova, I. Deposit date: 2022-03-22 Release date: 2022-07-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Interaction of CYP3A4 with Rationally Designed Ritonavir Analogues: Impact of Steric Constraints Imposed on the Heme-Ligating Group and the End-Pyridine Attachment. Int J Mol Sci, 23, 2022与抑制剂结合的细胞色素P450 3A4（CYP3A4）描述符：(2R)-3-苯基-2-({(2S)-3-苯基-2-[2-(吡啶-3-基)乙酰胺基]丙基}硫烷基)-N-[(吡啶-3-基)甲基]丙酰胺、细胞色素P450 3A4、含铁原卟啉IX 作者：谢夫柳科娃，I. 提交日期：2022-03-22 发布日期：2022-07-27 最后修改日期：2023-10-18 实验方法：X射线衍射（分辨率2.25埃） 引用文献：《合理设计的利托那韦类似物与CYP3A4的相互作用：血红素配位基团与末端吡啶连接体所受空间约束的影响》，《国际分子科学杂志》，23卷，2022年