Small RNA sequencing of 50 laryngeal squamous cell carcinoma and paired adjacent normal tissues

Laryngeal squamous cell carcinoma (LSCC) is a common form of head and neck cancer with poor prognosis. However, the mechanism underlying the pathogenesis of LSCC remains unclear. We performed high throughout sequencing to identify miRNA that associated with LSCC progression.Small RNA libraries were constructed followed by sequencing on a cohort of LSCC tissues (50 samples) and paired adjacent normal mucosa tissues (50 samples). Expression of miRNA in 50 LSCC and 50 paired adjacent normal mucosa tissues was examination by high throughout sequencing.