Nanostructured AABB Zn (II) phthalocyanines as photodynamic agents for bacterial inactivation [dataset]

<p>The ability of amphiphilic Phthalocyanine (Pc) photosensitizers
(PS) (Zn(II)Pcs PS1, PS2, and PS3) to assemble into cationic nanoparticles in
water and to photo-inactivate bacterial strains is demonstrated. All the
synthesized Zn(II)Pcs exhibit an AABB functionalization pattern, having a
binaphthyloxy-linked bisisoindole (AA) functionalized at the chiral binaphthol
core with branched (PS1) or linear (PS2 and PS3) poly-ammonium chains, and
two non-functionalized isoindole rings (BB). The aggregation behavior and the
stability of the nanoparticles formed by the three PS in water is studied by
UV–vis, fluorescence and circular dichroism (CD) spectroscopies, and their
shape and size is determined by transmission electron microscopy (TEM) and
dynamic light scattering (DLS). The PS nanoparticles prove efficient in the
photoinactivation of S. aureus and E. coli. Although PS2 and PS3 present
better photophysical features in their monomeric form (i.e., improved singlet
oxygen quantum yield), PS1 is more effective in killing both types of strains,
especially the gram-negative E. coli. This observation may derive from the low
stability found for PS1 nanoparticles, which easily disassemble after binding
to the bacteria surface, recovering the photophysical properties of the
non-aggregated species.</p>

<p>Structural and photophysical characterization of compounds (Raw data).</p>