Catalytic Enantioselective <i>O</i>‑Nitrosocarbonyl Aldol Reaction of β‑Dicarbonyl Compounds
收藏NIAID Data Ecosystem2026-03-07 收录
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资源简介：
The first example of a Cu-catalyzed asymmetric O-nitrosocarbonyl aldol reaction is described. This novel protocol allows convenient access to highly enantioenriched α-hydroxy-β-ketoesters including the antibacterial natural product kjellmanianone (up to 99% ee). MnO2 was introduced as a mild efficient oxidant for the in situ generation of nitrosocarbonyl species from hydroxamic acid derivatives.
创建时间：
2016-02-20
