Androgen Receptor Mutations Database

Androgen Receptor Gene Mutations Database is for all who are interested in mutations of the Androgen Receptor Gene. In light of the difficulty in getting new AR mutations published the curator will now accept new mutations that have not been published, provided that it is from a reputable research or clinical laboratory. The curator also strongly suggests that where possible, particularly in the case of new unique mutations that an attempt be made to at least confirm the pathogenicity of the putatative mutation, by showing that the mutation when transfected into a suitable expression system produces a mutant androgen receptor protein.

雄激素受体基因突变数据库旨在服务于所有对雄激素受体基因突变感兴趣的学者。鉴于新AR突变发表的难度，编者现接受尚未发表的突变案例，前提是这些案例来自信誉良好的研究或临床实验室。编者还强烈建议，在可能的情况下，尤其是针对新发现的独特突变，应努力至少确认疑似突变的致病性，通过展示该突变在适宜的表达系统中转染后能产生突变型雄激素受体蛋白。