CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH N2C=C(c1nc(nn1C2(C)O)CCc3nc(nn3C)N4CCCC4)C(F)(F)F, micromolar IC50=0.44215

CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH N2C=C(c1nc(nn1C2(C)O)CCc3nc(nn3C)N4CCCC4)C(F)(F)F, micromolar IC50=0.44215 Descriptor: (4S)-5-methyl-2-{2-[1-methyl-3-(pyrrolidin-1-yl)-1H-1,2,4-triazol-5-yl]ethyl}-8-(trifluoromethyl)[1,2,4]triazolo[1,5-c]pyrimidine, MAGNESIUM ION, ZINC ION, ... Authors: Joseph, C, Benz, J, Flohr, A, Lerner, C, Rudolph, M.G. Deposit date: 2022-02-01 Release date: 2022-10-12 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.13 Å) Cite: Crystal Structure of a human phosphodiesterase 10 complex To be published

人类磷酸二酯酶10（human phosphodiesterase 10）与配体N2C=C(c1nc(nn1C2(C)O)CCc3nc(nn3C)N4CCCC4)C(F)(F)F结合的晶体结构，其微摩尔级半最大抑制浓度（IC50）为0.44215。描述符：(4S)-5-甲基-2-{2-[1-甲基-3-(吡咯烷-1-基)-1H-1,2,4-三唑-5-基]乙基}-8-(三氟甲基)[1,2,4]三唑并[1,5-c]嘧啶；体系包含镁离子、锌离子等。作者：Joseph, C、Benz, J、Flohr, A、Lerner, C、Rudolph, M.G.。沉积日期：2022-02-01；发布日期：2022-10-12；最后修改日期：2024-10-16。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.13埃（Å）。引用文献：《人类磷酸二酯酶10复合物晶体结构》（Crystal Structure of a human phosphodiesterase 10 complex），待发表。