Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z57260516 (A71EV2A-x0387)

Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z57260516 (A71EV2A-x0387) Descriptor: 2-methoxy-~{N}-(2,4,6-trimethylphenyl)ethanamide, DIMETHYL SULFOXIDE, Protease 2A, ... Authors: Lithgo, R.M, Fairhead, M, Koekemoer, L, Balcomb, B.H, Capkin, E, Chandran, A.V, Golding, M, Godoy, A.S, Aschenbrenner, J.C, Marples, P.G, Ni, X, Thompson, W, Tomlinson, C.W.E, Wild, C, Winokan, M, Xavier, M.-A.E, Fearon, D, von Delft, F. Deposit date: 2024-04-04 Release date: 2024-04-24 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.37 Å) Cite: Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals. Biorxiv, 2024

柯萨奇病毒A16（Coxsackievirus A16）2A蛋白酶晶体学片段筛选集群提交——柯萨奇病毒A16（G-10株）2A蛋白酶与Z57260516（A71EV2A-x0387）复合物的晶体结构。描述符：2-甲氧基-N-(2,4,6-三甲基苯基)乙酰胺、二甲基亚砜（DIMETHYL SULFOXIDE）、2A蛋白酶（Protease 2A）……。作者：Lithgo, R.M.、Fairhead, M、Koekemoer, L、Balcomb, B.H.、Capkin, E、Chandran, A.V.、Golding, M、Godoy, A.S.、Aschenbrenner, J.C.、Marples, P.G.、Ni, X、Thompson, W、Tomlinson, C.W.E.、Wild, C、Winokan, M、Xavier, M.-A.E.、Fearon, D、von Delft, F.。提交日期：2024年4月4日；发布日期：2024年4月24日；最后修改日期：2024年10月16日。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.37埃）。引用文献：《柯萨奇病毒A16 2A蛋白酶晶体学片段筛选发现广谱抗肠病毒药物开发新方向》，BioRxiv，2024年