The structure of Phenylethanolamine N-methyltransferase in complex with S-adenosylhomocysteine and an iodinated inhibitor

The structure of Phenylethanolamine N-methyltransferase in complex with S-adenosylhomocysteine and an iodinated inhibitor Descriptor: 7-IODO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE, Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE Authors: McMillan, F.M, Archbold, J, McLeish, M.J, Caine, J.M, Criscione, K.R, Grunewald, G.L, Martin, J.L. Deposit date: 2002-11-15 Release date: 2003-12-23 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase. J.Med.Chem., 47, 2004

本数据集为苯乙醇胺N-甲基转移酶（Phenylethanolamine N-methyltransferase）与S-腺苷同型半胱氨酸（S-adenosylhomocysteine）以及碘化抑制剂7-碘-1,2,3,4-四氢异喹啉（7-IODO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE）的复合物结构，相关标识信息如下：7-碘-1,2,3,4-四氢异喹啉、苯乙醇胺N-甲基转移酶、S-腺苷-L-同型半胱氨酸。作者：McMillan, F.M.、Archbold, J.、McLeish, M.J.、Caine, J.M.、Criscione, K.R.、Grunewald, G.L.、Martin, J.L. 提交日期：2002年11月15日；发布日期：2003年12月23日；最后修改日期：2024年2月14日。实验方法：X射线衍射（分辨率2.7 Å）。引用文献：《肾上腺素合成酶苯乙醇胺N-甲基转移酶对亚微摩尔级抑制剂的分子识别》，J.Med.Chem., 47, 2004。