Effects of exercise training on skeletal muscle insulin sensitivity in obesity patients undergoing RYGB surgery: a randomized controlled trial

We reported that skeletal muscle insulin sensitivity was restored to a lean phenotype with exercise training in patients undergoing RYGB surgery. For that, the goals of this study is to identify changes in the skeletal muscle transcriptome profiling (RNA-seq) that could explain the insulin sensitivity improvement of RYGB + exercise training group. Women patients with morbid obesity were undergone to RYGB and randomized to exercise training or not. Muscle biopsies were assessed before the RYGB surgery (PRE) and 9-month after RYGB surgery in both groups (RYGB and RYGB + exercise training). At baseline (PRE), muscle samples from lean control women were obtained as well.