Computational code underlying the publication “Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe”

Computational code to simulate the crosstalk between Bmp9 and Notch signaling in endothelial cells (and pericytes) within in vitro experiments or during sprouting angiogenesis. The objective of the research was to investigate the role that Bmp9-mediated upregulation of Lunatic Fringe expression plays in modulating the activity of Notch in cell culture and angiogenesis experiments. The results of the computational simulations were validated via in vitro and in vivo experiments.

本计算代码用于模拟体外实验或出芽型血管生成过程中，内皮细胞（及周细胞）内骨形态发生蛋白9（Bone Morphogenetic Protein 9）与Notch信号通路（Notch signaling）之间的信号串扰。本研究旨在探究Bmp9介导的边缘素（Lunatic Fringe）表达上调，在细胞培养与血管生成实验中对Notch通路活性的调控作用。计算模拟所得结果已通过体外及体内实验得到验证。