MuRF1 regulation of Fenofibrate’s induction of spontaneous cardiac hypertrophy in vivo.. Mus musculus

MuRF1 -/- w/ Fenofibrate treatment leads to the reduction of proteolytic and fibrolytic enzymes, increasing hypertrophy Overall design: Four strain-matched groups of 3-8 week old mice were investigated: 1) MuRF1 -/- Fenofibrate feed; 2) MuRF1 -/- chow feed; 3) MuRF1 +/+ Fenofibrate feed; 4) MuRF1 +/+ chow feed at two time points: 1) 3 weeks; 2) 8 Weeks Biological replicates: Two to three per condition. Hearts harvested. One replicate per array.