snATAC data analysis for Hidradentis Suppurativa patients' epidermis

In this study, we used single-nucleus ATAC-sequencing (snATAC-seq) to reveal how cellular heterogeneity of Hidradenitis Suppurativa (HS) lesional epidermis was reshaped at the genomic level. The Institutional Review Board of the University of Alabama at Birmingham approved the protocol (IRB-300005214) for obtaining surgically discarded skin tissues from heathy and HS (Hurley II/III stage) subjects. Surgical excisions from 2 patients with HS (axillary and groin lesions) and 2 healthy controls (discarded tissue from breast or abdominoplasty reduction surgery) were collected.