Replication Data for: Characterizing Active and Inactive Brown Adipose Tissue in Adult Humans Using PET-CT and MR Imaging

The purpose of this study is to characterize both active and inactive supraclavicular brown adipose tissue (BAT) in adults, and compare the values to those of subcutaneous white adipose tissue (WAT). We obtained 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) with x-ray computed tomography (CT) and magnetic resonance imaging (MRI) scans of 25 healthy adults. To the best of our knowledge this is the first study to quantify PET-CT and MRI fat signal fraction (FSF) measures, and utilize a semi-automated algorithm to identify inactive and active BAT in the same adult subjects. Our findings support the use of these metrics to characterize and distinguish between BAT and WAT, and lay the foundation for future MRI analysis with the hope that someday MRI-based delineation of BAT can stand on its own.本研究旨在对成人的活跃与非活跃锁骨上棕色脂肪组织（supraclavicular brown adipose tissue, BAT）开展特征表征，并将相关指标与皮下白色脂肪组织（subcutaneous white adipose tissue, WAT）进行对比。我们收集了25名健康成人的18F-氟代脱氧葡萄糖（18F-fluorodeoxyglucose, 18F-FDG）正电子发射计算机断层显像（positron emission tomography, PET）联合X射线计算机断层成像（x-ray computed tomography, CT）以及磁共振成像（magnetic resonance imaging, MRI）扫描数据。据我们所知，本研究为首项对PET-CT与MRI脂肪信号分数（fat signal fraction, FSF）指标进行定量分析，并采用半自动化算法在同一批成人受试者中识别非活跃与活跃BAT的研究。本研究结果证实了上述指标可用于表征并区分BAT与WAT，同时为后续MRI分析奠定了基础，以期未来基于MRI的BAT分割能够独立应用。