Aldose reductase inhibition decelerates optic nerve degeneration by suppressing retinal microglia activation
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE200233
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资源简介：
To investigate the role of aldose reductase (AR) inhibition using Sorbinil on retinal microglia (RMG) activation, retinal ganglion cell (RGC) survival, and axon regeneration after optic nerve trauma. We observed that AR inhibition using Sorbinil attenuates RMG activation and subsequently promotes RGC survival and delays axon degeneration one week after optic nerve crush. We performed RNA-seq on injured retina samples treated with DMSO or Sorbinil seven days after optic nerve crush. We wanted to to identify the regulatory mechanism that contributes to the delay of axonal degeneration after Sorbinil-dependent microglial inactivation.
创建时间：
2023-05-02
